Regulation of gene expression through biomolecular condensation

Speaker: dr Adam Kłosin (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany)

Talk: Regulation of gene expression through biomolecular condensation

Time: 06 November 2020, 9:00 am

Venue: Online in the "IFB seminars" group of MS Teams. Group password: ypidr3d.

Adam Kłosin is a postdoctoral researcher and a Marie Skłodowska-Curie Fellow at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. In 2016 he completed his PhD in the group of Ben Lehner at the Centre for Genomic Regulation in Barcelona where he studied mechanisms of epigenetic inheritance in Caenorhabditis elegans. He then moved to Dresden to train in the arts of biological phase separation in the group of Tony Hyman. In his research he applies biophysical methods to understand various aspects of gene regulation such as transcriptional initiation and control of protein expression variability. His most recent work demonstrates a very effective mechanism for noise reduction in mammalian cells based on compartmentalisation of a protein via liquid- liquid phase separation. He is currently investigating the role of disordered protein domains in regulating interactions with the DNA in the context of transcriptional initiation.